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Rabbit Anti-ZIC1 Monoclonal Antibody (EPR7291(2)) (CBMAB-1721-YC)

Provided herein is a rabbit monoclonal antibody against Human ZIC1. The antibody, clone EPR7291(2), can be used for immunoassay techniques, such as ICC, IF, FC and WB.
See all ZIC1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR7291(2)
Antibody Isotype
IgG
Application
ICC, IF, FC, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues within Human Zic1 (UniProt ID: Q15915).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ZIC1
Introduction
ZIC1 is a member of the ZIC family of C2H2-type zinc finger proteins. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor.
Entrez Gene ID
Human7545
Mouse22771
Rat64618
UniProt ID
HumanQ15915
MouseP46684
RatQ9JKY2
Alternative Names
ZIC; CRS6; ZNF201
Function
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
Biological Process
Biological Process adult walking behavior Source:Ensembl
Biological Process brain development Source:UniProtKB1 Publication
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process central nervous system development Source:GO_Central1 Publication
Biological Process hippocampus development Source:Ensembl
Biological Process inner ear morphogenesis Source:UniProtKB
Biological Process maintenance of cell number Source:Ensembl
Biological Process olfactory bulb development Source:Ensembl
Biological Process pattern specification process Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB
Biological Process positive regulation of protein import into nucleus Source:UniProtKB
Biological Process regulation of smoothened signaling pathway Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process spinal cord development Source:Ensembl
Cellular Location
Nucleus
Cytoplasm
Localizes in the cytoplasm in presence of MDFIC overexpression.
Involvement in disease
Craniosynostosis 6 (CRS6):
A form of craniosynostosis, a primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
Structural brain anomalies with impaired intellectual development and craniosynostosis (BAIDCS):
A disease characterized by microcephaly, agenesis of corpus callosum, abnormal conformation of the ventricles and posterior fossa, hypoplasia of both cerebellar hemispheres, colpocephaly, and partial absence of the cerebellar vermis with fusion of the cerebellar hemispheres. Intellectual development is moderately to severely impaired. Bicoronal synostosis, scoliosis, and tethered cord may be present.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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