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Mouse Anti-ZNFN1A3 Recombinant Antibody (3H5-G7) (CBMAB-A10230-LY)

The product is antibody recognizes ZNFN1A3. The antibody 3H5-G7 immunoassay techniques such as: IF, ELISA.
See all ZNFN1A3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H5-G7
Antibody Isotype
IgG2b, κ
Application
IF, ELISA

Basic Information

Immunogen
ZNFN1A3 (AAH32707, 1 a.a. ~ 509 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
IKAROS family zinc finger 3 (Aiolos)
Introduction
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. [provided by RefSeq]
Entrez Gene ID
22806
UniProt ID
Q9UKT9
Alternative Names
AIO; AIOLOS; ZNFN1A3
Function
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Biological Process
B cell activation Source: UniProtKB-KW
Mesoderm development Source: ProtInc
Regulation of apoptotic process Source: UniProtKB
Regulation of B cell differentiation Source: UniProtKB
Regulation of B cell proliferation Source: UniProtKB
Regulation of lymphocyte differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to bacterium Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
PTM
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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