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CFHR1 Matched Antibody Pair (265) (APMAB-265LY)

This antibody pair set can be used for detecting and quantifying protein level of human CFHR1.
See all CFHR1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-CFHR1 monoclonal, IgG2b antibody, 100 ug
Detection Antibody
Anti-CFHR1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
Alternative Names
Complement Factor H Related 1; Complement Factor H-Related 1 Pseudogene; H Factor (Complement)-Like 1; H Factor (Complement)-Like 2; H Factor-Like Protein 1; H-Factor-Like 1; CFHL1P; CFHR1P; CFHL1; FHR-1;
Entrez Gene ID
3078
UniProt ID
Q03591

Skerka, C., Pradel, G., Halder, L. D., Zipfel, P. F., Zipfel, S. L., & Strauß, O. (2021). Factor H‐related protein 1: a complement regulatory protein and guardian of necrotic‐type surfaces. British Journal of Pharmacology, 178(14), 2823-2831.

Irmscher, S., Zipfel, S. L., Halder, L. D., Ivanov, L., Gonzalez-Delgado, A., Waldeyer, C., ... & Skerka, C. (2021). Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease. Scientific reports, 11(1), 1-15.

van Beek, A. E., Pouw, R. B., Brouwer, M. C., van Mierlo, G., Geissler, J., Ooijevaar-de Heer, P., ... & Kuijpers, T. W. (2017). Factor H-related (FHR)-1 and FHR-2 form homo-and heterodimers, while FHR-5 circulates only as homodimer in human plasma. Frontiers in immunology, 8, 1328.

Medjeral-Thomas, N. R., Lomax-Browne, H. J., Beckwith, H., Willicombe, M., McLean, A. G., Brookes, P., ... & Pickering, M. C. (2017). Circulating complement factor H–related proteins 1 and 5 correlate with disease activity in IgA nephropathy. Kidney international, 92(4), 942-952.

Trojnár, E., Józsi, M., Uray, K., Csuka, D., Szilágyi, Á., Milosevic, D., ... & Prohászka, Z. (2017). Analysis of linear antibody epitopes on factor H and CFHR1 using sera of patients with autoimmune atypical hemolytic uremic syndrome. Frontiers in immunology, 8, 302.

Tortajada, A., Gutiérrez, E., de Jorge, E. G., Anter, J., Segarra, A., Espinosa, M., ... & de Córdoba, S. R. (2017). Elevated factor H–related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy. Kidney international, 92(4), 953-963.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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