Sign in or Register   Sign in or Register
  |  

Mouse Anti-NAMPT/Visfatin Recombinant Antibody (2E11-F7-G3) (CBMAB-Z0328-LY)

The product is antibody recognizes NAMPT/Visfatin. The antibody 2E11-F7-G3 immunoassay techniques such as: WB.
See all NAMPT/Visfatin antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E11-F7-G3
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of PBEF1 (aa338-479) expressed in E. Coli.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nicotinamide Phosphoribosyltransferase
Entrez Gene ID
10135
UniProt ID
P43490
Alternative Names
VF; PBEF; PBEF1; VISFATIN; NAMPT
Function
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Biological Process
Cell-cell signaling Source: ProtInc
Circadian regulation of gene expression Source: UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathway Source: Reactome
NAD biosynthetic process Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Cytoplasm
Secreted
Note: Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NAMPT/Visfatin Recombinant Antibody (2E11-F7-G3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare