4-Aminobiphenyl

4-amino Biphenyl (4-ABP) is an arylamine (aromatic amine) compound and as one of the major carcinogenic constituents of tobacco smoke other environmental sources, it poses critical health hazards to human beings. Under the action of carcinogen activating biotransformation enzymes such as cytochrome P4501A2, 4-ABP gets metabolized to generate a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Nevertheless, the accumulation of biologically active metabolites is dependent on the balance between activation and detoxification enzymes. 4-ABP has been linked to bladder and breast cancers in human beings as well as in rodent models. Our 4-amino Biphenyl DNA antibody (4C11) is a monoclonal antiserum which recognizes 4-aminobiphenyl (4-ABP)-DNA adducts and it has been characterized by competitive enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC) and Immunocytochemistry/Immunofluorescence (ICC/IF) techniques. This antibody does not recognize the DNA adducts of several other aromatic amines tested including 1-aminopyrene, 8-nitro-1-aminopyrene, and 6-nitro-1-aminopyrene.

4-Aminobiphenyl