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ABCB1

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Full Name
ATP Binding Cassette Subfamily B Member 1
Function
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Biological Process
Carboxylic acid transmembrane transport
Ceramide translocation
Export across plasma membrane
G2/M transition of mitotic cell cycle
Phospholipid translocation
Positive regulation of anion channel activity
Regulation of chloride transport
Regulation of response to osmotic stress
Response to drug
Stem cell proliferation
Terpenoid transport
Transepithelial transport
Transmembrane transport
Transport across blood-brain barrier
Xenobiotic transport across blood-brain barrier
Cellular Location
Cell membrane; Apical cell membrane
Involvement in disease
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Topology
Cytoplasmic: 1-44 aa
Helical: 45-67 aa
Extracellular: 68-116 aa
Helical: 117-137 aa
Cytoplasmic: 138-186 aa
Helical: 187-208 aa
Extracellular: 209-215 aa
Helical: 216-236 aa
Cytoplasmic: 237-292 aa
Helical: 293-316 aa
Extracellular: 317-330 aa
Helical: 331-352 aa
Cytoplasmic: 353-771 aa
Helical: 772-732 aa
Extracellular: 733-756 aa
Helical: 757-777 aa
Cytoplasmic: 778-832 aa
Helical: 833-853 aa
Extracellular: 854 aa
Helical: 855-874 aa
Cytoplasmic: 875-934 aa
Helical: 935-957 aa
Extracellular: 958-973 aa
Helical: 974-995 aa
Cytoplasmic: 996-1280 aa

Anti-ABCB1 antibodies

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Target: ABCB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-178922
Application*: WB
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-178924
Application*: IH
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178928
Application*: WB, IH
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-178931
Application*: E, WB
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178935
Application*: P, WB
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-178954
Application*: P, WB
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-178957
Application*: WB, IH
Target: ABCB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: V2-178959
Application*: WB, IP
Target: ABCB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-178960
Application*: WB, IP, IF
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178963
Application*: F, IC, C, P, WB
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178966
Application*: IC, C, P, WB
Target: ABCB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-610675
Application*: F, IF, IHC, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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