ABCF1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
Full Name
ATP Binding Cassette Subfamily F Member 1
Function
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
Biological Process
Inflammatory response
Positive regulation of translation
Translation
Translational initiation
Transmembrane transport
Cellular Location
Nucleoplasm; Nucleus envelope; Cytoplasm
PTM
Isoform 2 is phosphorylated at phosphoserine and phosphothreonine. Isoform 2 phosphorylation on Ser-109 and Ser-140 by CK2 inhibits association of EIF2 with ribosomes.
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Anti-ABCF1 antibodies

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Mouse Anti-ABCF1 Recombinant Antibody (V2-179068) (CBMAB-A0304-YC)

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Target: ABCF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-179068
Application*: IF, E
Datasheet SDS

Mouse Anti-ABCF1 Recombinant Antibody (V2-179067) (CBMAB-A0303-YC)

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Target: ABCF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179067
Application*: DB, IP
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Mouse Anti-ABCF1 Recombinant Antibody (V2-179065) (CBMAB-A0301-YC)

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Target: ABCF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-179065
Application*: E, IC, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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