ACKR2

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Full Name

Atypical Chemokine Receptor 2

Biological Process

Calcium-mediated signaling
Cell chemotaxis
Chemotaxis
G protein-coupled receptor signaling pathway
Immune response
Inflammatory response
Multicellular organism development
Positive regulation of cytosolic calcium ion concentration

Cellular Location

Early endosome; Recycling endosome; Cell membrane. Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Topology

Extracellular: 1-50 aa
Helical: 51-71 aa
Cytoplasmic: 72-92 aa
Helical: 93-113 aa
Extracellular: 114-118 aa
Helical: 119-140 aa
Cytoplasmic: 141-162 aa
Helical: 163-183 aa
Extracellular: 184-217 aa
Helical: 218-238 aa
Cytoplasmic: 239-250 aa
Helical: 251-271 aa
Extracellular: 272-293 aa
Helical: 294-314 aa
Cytoplasmic: 315-384 aa

PTM

Phosphorylated on serine residues in the C-terminal cytoplasmic tail.