ADSL

ADSL belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to a
Full Name
Adenylosuccinate Lyase
Function
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Biological Process
de novo' AMP biosynthetic process
'de novo' IMP biosynthetic process
AMP biosynthetic process
Purine nucleotide biosynthetic process
Purine ribonucleoside monophosphate biosynthetic process
Cellular Location
Cytosol; Protein-containing complex
Involvement in disease
Adenylosuccinase deficiency (ADSLD): An autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present.
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Anti-ADSL antibodies

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Rabbit Anti-ADSL Recombinant Antibody (V2-180030) (CBMAB-A1432-YC)

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Target: ADSL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180030
Application*: WB, P, IP
Datasheet SDS

Rabbit Anti-ADSL Recombinant Antibody (V2-180029) (CBMAB-A1431-YC)

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Target: ADSL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180029
Application*: E
Datasheet SDS

Mouse Anti-ADSL Recombinant Antibody (V2-180028) (CBMAB-A1430-YC)

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Target: ADSL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: V2-180028
Application*: E, IH, P, WB
Datasheet SDS

Mouse Anti-ADSL Recombinant Antibody (V2-180027) (CBMAB-A1429-YC)

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Target: ADSL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180027
Application*: WB, F, E, IC, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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