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ADSL

ADSL belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to a

Full Name

Adenylosuccinate Lyase

Function

Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.

Biological Process

de novo' AMP biosynthetic process
'de novo' IMP biosynthetic process
AMP biosynthetic process
Purine nucleotide biosynthetic process
Purine ribonucleoside monophosphate biosynthetic process

Cellular Location

Cytosol; Protein-containing complex

Involvement in disease

Adenylosuccinase deficiency (ADSLD): An autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present.

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Anti-ADSL antibodies

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Rabbit Anti-ADSL Recombinant Antibody (V2-180030) (CBMAB-A1432-YC)

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Target: ADSL

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-180030

Application*: WB, P, IP

Rabbit Anti-ADSL Recombinant Antibody (V2-180029) (CBMAB-A1431-YC)

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Target: ADSL

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-180029

Application*: E

Mouse Anti-ADSL Recombinant Antibody (V2-180028) (CBMAB-A1430-YC)

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Target: ADSL

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: V2-180028

Application*: E, IH, P, WB

Mouse Anti-ADSL Recombinant Antibody (V2-180027) (CBMAB-A1429-YC)

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Target: ADSL

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180027

Application*: WB, F, E, IC, IF

Human Recombinant ADSL protein, His Tag (V2LY-0526-LY1950)

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Target: ADSL

Expressed Host: E. coli

Sequence: Amino Acid: 1-484

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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