CAMSAP2

CAMSAP2 (Calmodulin Regulated Spectrin Associated Protein Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding and microtubule minus-end binding. An important paralog of this gene is CAMSAP1.

Full Name

Calmodulin Regulated Spectrin Associated Protein Family Member 2

Function

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919).
Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919).
Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919).
In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919).
Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745).
Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745).
Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486).
Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242).

Biological Process

Axon development Source: UniProtKB
Cytoplasmic microtubule organization Source: GO_Central
Microtubule cytoskeleton organization Source: UniProtKB
Negative regulation of microtubule depolymerization Source: GO_Central
Regulation of dendrite development Source: UniProtKB
Regulation of Golgi organization Source: UniProtKB
Regulation of microtubule polymerization Source: UniProtKB
Regulation of organelle organization Source: UniProtKB

Cellular Location

Golgi apparatus; Cytoskeleton; Cilium basal body; Cytoplasm. Associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:23169647, PubMed:24486153, PubMed:24908486, PubMed:24706919, PubMed:27666745, PubMed:28814570). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). The length of CAMSAP2-decorated stretches on the minus-end of microtubules depends on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches (PubMed:28814570). Recruited to the Golgi apparatus by AKAP9 and PDE4DIP isoform 13/MMG8/SMYLE (PubMed:27666745). In neurons, localizes to the minus-end of microtubules in axon and dendrites (PubMed:24908486).