CDCA7L
CDCA7L (Cell Division Cycle Associated 7 Like) is a Protein Coding gene. Diseases associated with CDCA7L include Medulloblastoma. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. An important paralog of this gene is CDCA7.
Full Name
Cell Division Cycle Associated 7 Like
Function
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Biological Process
Positive regulation of cell population proliferation Source: MGI
Regulation of transcription, DNA-templated Source: InterPro
Regulation of transcription, DNA-templated Source: InterPro
Cellular Location
Cytoplasm; Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
PTM
Phosphorylation increases its interaction with PSIP1.
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Anti-CDCA7L antibodies
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Target: CDCA7L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2164
Application*: WB, IH
Target: CDCA7L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1697
Application*: WB, IH
Target: CDCA7L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1532
Application*: WB, IH
Target: CDCA7L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B5
Application*: WB, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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