Sign in or Register   Sign in or Register
  |  

CDH4

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. [provided by RefSeq]
Full Name
Cadherin 4
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Biological Process
Adherens junction organization Source: Reactome
Axon guidance Source: Ensembl
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Positive regulation of axon extension Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 170-734
Helical: 735-756
Cytoplasmic: 757-916

Anti-CDH4 antibodies

Loading...
Target: CDH4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2567
Application*: WB, IH
Target: CDH4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1564
Application*: WB
Target: CDH4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MRCD5
Application*: WB
Target: CDH4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E2
Application*: E, WB
Target: CDH4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG594
Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000
Target: CDH4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1744
Application*: P, WB
Target: CDH4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C1742
Application*: WB
Target: CDH4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR4836
Application*: IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare