DAAM2

DAB1-AS1 (DAB1 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

Full Name

dishevelled associated activator of morphogenesis 2

Function

Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.

Biological Process

Actin cytoskeleton organization Source: InterPro
Dorsal spinal cord development Source: UniProtKB
Negative regulation of oligodendrocyte differentiation Source: UniProtKB
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Regulation of canonical Wnt signaling pathway Source: UniProtKB
Regulation of non-canonical Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Extracellular exosome