DBF4

DBF4 (DBF4 Zinc Finger) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and enzyme activator activity. An important paralog of this gene is DBF4B.
Full Name
DBF4 Zinc Finger
Function
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Biological Process
DNA replication Source: Reactome
DNA replication initiation Source: Reactome
G1/S transition of mitotic cell cycle Source: ProtInc
Positive regulation of nuclear cell cycle DNA replication Source: GO_Central
Regulation of cell cycle phase transition Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation increases its interaction with PSIP1.
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Anti-DBF4 antibodies

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Mouse Anti-DBF4 Recombinant Antibody (6G9) (CBMAB-D0282-YC)

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Target: DBF4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6G9
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-DBF4 Recombinant Antibody (
24D8) (V2LY-0725-LY965)

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Target: DBF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 24D8
Application*: E, WB, IF
Datasheet SDS

Rabbit Anti-DBF4 Recombinant Antibody (EG927) (CBMAB-EN1099-LY)

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Target: DBF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG927
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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