DIP2A
The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
                Full Name
                    DIP2 disco-interacting protein 2 homolog A (Drosophila)
                Function
                    Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity).
Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity).
Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002).
                Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity).
Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002).
Biological Process
                    Acetyl-CoA biosynthetic process Source: UniProtKB
Dendritic spine morphogenesis Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Positive regulation of peptidyl-lysine acetylation Source: UniProtKB
                Dendritic spine morphogenesis Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Positive regulation of peptidyl-lysine acetylation Source: UniProtKB
Cellular Location
                    Cell membrane; Mitochondrion; Dendritic spine
                
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                    Anti-DIP2A antibodies
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        Target: DIP2A
                
                Host: Mouse
                
                Antibody Isotype: IgG2a
                
                Specificity: Human
                
                Clone: 4E6
                
                Application*: E, WB
                
            Target: DIP2A
                
                Host: Mouse
                
                Antibody Isotype: IgG2a, κ
                
                Specificity: Human
                
                Clone: 1013
                
                Application*: E, IP, WB
                
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For Research Use Only. Not For Clinical Use.
                    (P): Predicted
* Abbreviations 
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
 
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