DRD3

DRD3 is the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

Dopamine Receptor D3

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Acid secretion Source: BHF-UCL
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
Adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
Arachidonic acid secretion Source: BHF-UCL
Autophagy Source: Ensembl
Behavioral response to cocaine Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Circadian regulation of gene expression Source: BHF-UCL
Dopamine metabolic process Source: BHF-UCL
Gastric emptying Source: Ensembl
G protein-coupled receptor internalization Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: BHF-UCL
Learning Source: BHF-UCL
Learning or memory Source: BHF-UCL
Locomotory behavior Source: BHF-UCL
Musculoskeletal movement, spinal reflex action Source: BHF-UCL
Negative regulation of adenylate cyclase activity Source: GO_Central
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of blood pressure Source: BHF-UCL
Negative regulation of cytosolic calcium ion concentration Source: GO_Central
Negative regulation of oligodendrocyte differentiation Source: BHF-UCL
Negative regulation of protein kinase B signaling Source: BHF-UCL
Negative regulation of protein secretion Source: BHF-UCL
Negative regulation of sodium:proton antiporter activity Source: Ensembl
Negative regulation of synaptic transmission, glutamatergic Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of voltage-gated calcium channel activity Source: GO_Central
Phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of cytokinesis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
Positive regulation of mitotic nuclear division Source: BHF-UCL
Positive regulation of renal sodium excretion Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Prepulse inhibition Source: BHF-UCL
Regulation of circadian sleep/wake cycle, sleep Source: Ensembl
Regulation of dopamine secretion Source: BHF-UCL
Regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Regulation of locomotion involved in locomotory behavior Source: Ensembl
Regulation of postsynaptic neurotransmitter receptor internalization Source: Ensembl
Regulation of potassium ion transport Source: GO_Central
Response to cocaine Source: BHF-UCL
Response to drug Source: BHF-UCL
Response to histamine Source: BHF-UCL
Response to morphine Source: BHF-UCL
Social behavior Source: BHF-UCL
Visual learning Source: BHF-UCL

Cell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Tremor, hereditary essential 1 (ETM1):
A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

Extracellular: 1-32
Helical: 33-55
Cytoplasmic: 56-65
Helical: 66-88
Extracellular: 89-104
Helical: 105-126
Cytoplasmic: 127-149
Helical: 150-170
Extracellular: 171-187
Helical: 188-209
Cytoplasmic: 210-329
Helical: 330-351
Extracellular: 352-366
Helical: 367-386
Cytoplasmic: 387-400

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
Palmitoylated.