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DVL3

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Full Name
Dishevelled Segment Polarity Protein 3
Research Area
Involved in the signal transduction pathway mediated by multiple Wnt genes.
Biological Process
Canonical Wnt signaling pathway Source: BHF-UCL
Intracellular signal transduction Source: InterPro
Non-canonical Wnt signaling pathway Source: BHF-UCL
Non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
Planar cell polarity pathway involved in neural tube closure Source: GO_Central
Positive regulation of GTPase activity Source: ParkinsonsUK-UCL
Positive regulation of JUN kinase activity Source: BHF-UCL
Positive regulation of neuron projection arborization Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein stabilization Source: ParkinsonsUK-UCL
Regulation of cellular protein localization Source: ParkinsonsUK-UCL
Response to drug Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
Cellular Location
Cytoplasm
Involvement in disease
Robinow syndrome, autosomal dominant 3 (DRS3):
A form of Robinow syndrome, a rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, genital hypoplasia, renal anomalies, and costovertebral segmentation defects.
PTM
Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
Phosphorylated by CSNK1D.
Arginine methylation may function as a switch in regulation of function in Wnt signaling.
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Anti-DVL3 antibodies

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Mouse Anti-DVL3 Monoclonal Antibody (2E12) (CBMAB-0319-YC)

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Target: DVL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2E12
Application*: IP, WB
Datasheet SDS

Mouse Anti-DVL3 Monoclonal Antibody (1B10) (CBMAB-0317-YC)

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Target: DVL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1B10
Application*: IP
Datasheet SDS

Mouse Anti-DVL3 Monoclonal Antibody (1A11) (CBMAB-0315-YC)

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Target: DVL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 1A11
Application*: IP, WB
Datasheet SDS

Mouse Anti-DVL3 Recombinant Antibody (D1942) (V2LY-0425-LY1122)

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Target: DVL3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D1942
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DVL3 Recombinant Antibody (D1939) (V2LY-0425-LY1120)

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Target: DVL3
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: D1939
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DVL3 Recombinant Antibody (D1940) (CBMAB-D1940-YC)

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Target: DVL3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D1940
Application*: IP, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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