EDF1

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. [provided by RefSeq]

Full Name

EDF1

Research Area

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.

Biological Process

Endothelial cell differentiation Source: UniProtKB
Multicellular organism development Source: ProtInc
Positive regulation of DNA binding Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of lipid metabolic process Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.

PTM

Phosphorylated (by PKA and PKC).