EHD3

EHD3 (EH Domain Containing 3) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Endocytosis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and GTP binding. An important paralog of this gene is EHD1.

Full Name

EH-domain containing 3

Research Area

ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250).

In vitro causes tubulation of endocytic membranes (PubMed:24019528).

Binding to phosphatidic acid induces its membrane tubulation activity (By similarity).

Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025).

Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287).

Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164).

Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity).

In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity).

Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025).

Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity).

Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250).

Biological Process

Cilium assembly Source: UniProtKB
Early endosome to Golgi transport Source: UniProtKB
Endocytic recycling Source: UniProtKB
Endocytosis Source: GO_Central
Endosomal transport Source: GO_Central
Golgi to lysosome transport Source: UniProtKB
Positive regulation of voltage-gated calcium channel activity Source: Ensembl
Protein homooligomerization Source: UniProtKB
Protein localization to plasma membrane Source: MGI
Protein transport Source: UniProtKB-KW
Receptor recycling Source: UniProtKB
Regulation of cardiac conduction Source: Ensembl
Regulation of cardiac muscle cell membrane potential Source: MGI
Regulation of cardiac muscle contraction Source: Ensembl
Regulation of Golgi organization Source: UniProtKB

Cellular Location

Recycling endosome membrane; Cell membrane; Cilium membrane. Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (By similarity). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:20489164). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity).