EIF4B

EIF4B (Eukaryotic Translation Initiation Factor 4B) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is EIF4H.

Full Name

Eukaryotic Translation Initiation Factor 4B

Research Area

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Biological Process

Eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: ProtInc

Cellular Location

Cytosol; Dendrite; Eukaryotic translation initiation factor 4F complex; Neuronal cell body; Postsynapse

PTM

Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.

Anti-EIF4B antibodies

Mouse Anti-EIF4B Recombinant Antibody (CBFYE-0703) (CBMAB-E1127-FY)

Datasheet

SDS

Target: EIF4B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBFYE-0703

Application*: WB, F, E, IH, IF, MC

Mouse Anti-EIF4B Recombinant Antibody (CBFYE-0184) (CBMAB-E0427-FY)

Datasheet

SDS

Target: EIF4B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-0184

Application*: WB

Mouse Anti-EIF4B Recombinant Antibody (355CT12.6.5) (CBMAB-E0191-FY)

Datasheet

SDS

Target: EIF4B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 355CT12.6.5

Application*: E, WB

Rat Anti-EIF4B (Phosphorylated S422) Recombinant Antibody (866049) (PTM-CBMAB-0487LY)

Datasheet

SDS

Target: EIF4B

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: 866049

Application*: WB

Mouse Anti-EIF4B Recombinant Antibody (1F5) (CBMAB-CP0564-LY)

Datasheet

SDS

Target: EIF4B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1F5

Application*: WB, P, IF (IC)

Mouse Anti-EIF4B Recombinant Antibody (4C3-D4-E3) (CBMAB-Z0212-LY)

Datasheet

SDS

Target: EIF4B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: 4C3-D4-E3

Application*: WB, IH, IC, F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)