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EIF4B

EIF4B (Eukaryotic Translation Initiation Factor 4B) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is EIF4H.
Full Name
Eukaryotic Translation Initiation Factor 4B
Research Area
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Biological Process
Eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: ProtInc
Cellular Location
Cytosol; Dendrite; Eukaryotic translation initiation factor 4F complex; Neuronal cell body; Postsynapse
PTM
Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.
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Anti-EIF4B antibodies

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Rat Anti-EIF4B (Phospho-S422) Recombinant Antibody (49) (PTM-CBMAB-0487LY)

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Target: EIF4B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 49
Application*: WB
Datasheet SDS

Mouse Anti-EIF4B Recombinant Antibody (1F5) (CBMAB-CP0564-LY)

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Target: EIF4B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 1F5
Application*: E, IF, F, WB, P
Datasheet SDS

Mouse Anti-EIF4B Recombinant Antibody (CBT2356) (V2LY-0625-LY2763)

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Target: EIF4B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBT2356
Application*: WB, IH, IC, F
Datasheet SDS

Rabbit Anti-EIF4B (Phospho-Ser422) Recombinant Antibody (EG1069) (V2LY-0425-LY1726)

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Target: EIF4B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1069
Application*: WB, IF, F, P
Datasheet SDS

Rabbit Anti-EIF4B (Phospho-S406) Recombinant Antibody (E0191) (V2LY-0425-LY1721)

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Target: EIF4B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: E0191
Application*: WB
Datasheet SDS

Mouse Anti-EIF4B Recombinant Antibody (CBFYE-0703) (CBMAB-E1127-FY)

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Target: EIF4B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0703
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-EIF4B Recombinant Antibody (CBFYE-0184) (CBMAB-E0427-FY)

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Target: EIF4B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog
Clone: CBFYE-0184
Application*: E, IF, IP, WB, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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