EVPL

This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]

Envoplakin

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.

Epidermis development Source: ProtInc
Intermediate filament cytoskeleton organization Source: GO_Central
Keratinization Source: UniProtKB-KW
Keratinocyte differentiation Source: UniProtKB
Peptide cross-linking Source: UniProtKB
Wound healing Source: GO_Central

Cytoskeleton; Desmosome; Cornified envelope. Colocalized with DSP at desmosomes and along intermediate filaments.