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FATE1

This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation.
Full Name
fetal and adult testis expressed 1
Research Area
Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca2+ transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544).

May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of mitochondrial calcium ion concentration Source: UniProtKB
Cellular Location
Mitochondrion; Mitochondrion outer membrane; Endoplasmic reticulum membrane. Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER.
Topology
Helical: 163-181

Anti-FATE1 antibodies

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Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A1
Application*: IF, P, WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D7
Application*: WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E2
Application*: F, IF, WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3595
Application*: IF, WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G10
Application*: WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A11
Application*: WB, P, IF
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0351
Application*: E, WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A8
Application*: IF, P, WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B12
Application*: WB, IF
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B5
Application*: WB, IH, IF
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2872
Application*: E, IH, WB
Target: FATE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B11
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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