FOXC2

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]

FOXC2

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.

Anatomical structure morphogenesis Source: GO_Central
Artery morphogenesis Source: Ensembl
Blood vessel diameter maintenance Source: Ensembl
Blood vessel remodeling Source: Ensembl
Branching involved in blood vessel morphogenesis Source: Ensembl
Camera-type eye development Source: Ensembl
Cardiac muscle cell proliferation Source: Ensembl
Cell differentiation Source: GO_Central
Collagen fibril organization Source: Ensembl
Embryonic heart tube development Source: Ensembl
Embryonic viscerocranium morphogenesis Source: Ensembl
Glomerular endothelium development Source: Ensembl
Glomerular mesangial cell development Source: Ensembl
Glomerular visceral epithelial cell differentiation Source: Ensembl
Heart development Source: DFLAT
Insulin receptor signaling pathway Source: UniProtKB
Lymphangiogenesis Source: UniProtKB
Mesoderm development Source: UniProtKB
Metanephros development Source: Ensembl
Negative regulation of apoptotic process involved in outflow tract morphogenesis Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Neural crest cell development Source: Ensembl
Notch signaling pathway Source: Ensembl
Ossification Source: Ensembl
Paraxial mesodermal cell fate commitment Source: Ensembl
Positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of endothelial cell migration Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of vascular wound healing Source: BHF-UCL
Regulation of organ growth Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to hormone Source: UniProtKB
Somitogenesis Source: Ensembl
Ureteric bud development Source: Ensembl
Vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Ventricular cardiac muscle tissue morphogenesis Source: Ensembl

Nucleus

Lymphedema-distichiasis syndrome (LPHDST):
An autosomal dominant disorder characterized by primary limb lymphedema associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices). Swelling of the extremities, due to altered lymphatic flow, usually appears in late childhood or puberty. Most affected individuals have ocular findings including corneal irritation, recurrent conjunctivitis, and photophobia. Drooping of the upper eyelid (ptosis) is a variable feature of the lymphedema-distichiasis syndrome, occurring in about 30% of patients.

Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.