FOXM1

The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Full Name
Forkhead Box M1
Function
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
DNA repair Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Negative regulation of cell aging Source: UniProtKB
Negative regulation of stress-activated MAPK cascade Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of double-strand break repair Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of cell cycle Source: BHF-UCL
Regulation of cell growth Source: UniProtKB
Regulation of cell population proliferation Source: GO_Central
Regulation of Ras protein signal transduction Source: BHF-UCL
Regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.
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Anti-FOXM1 antibodies

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Mouse Anti-FOXM1 Recombinant Antibody (CAP787) (CBMAB-AP2381LY)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CAP787
Application*: E, WB
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-2029) (CBMAB-F1622-CQ)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2029
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-3744) (CBMAB-F1515-CQ)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-3744
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FOXM1 Monoclonal Antibody (1H4) (CBMAB-0387-YC)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 1H4
Application*: WB, IP
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-2356) (V2LY-0925-LY2933)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-2356
Application*: E, WB
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0849) (V2LY-0925-LY2932)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0849
Application*: E, WB
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0848) (V2LY-0925-LY2931)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0848
Application*: IF, E, WB
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBT4203) (V2LY-0625-LY384)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4203
Application*: F
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (2H4) (CBMAB-A3130-LY)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H4
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-3168) (CBMAB-F3864-CQ)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-3168
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0847) (CBMAB-F3205-CQ)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0847
Application*: E, F
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-2357) (CBMAB-F2817-CQ)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2357
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-FOXM1 Recombinant Antibody (CBXF-1143) (CBMAB-F0956-CQ)

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Target: FOXM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1143
Application*: WB, IF
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-1300) (CBMAB-F0955-CQ)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-1300
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0850) (CBMAB-F0678-CQ)

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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-0850
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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