GART

The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase

de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Adenine biosynthetic process Source: GO_Central
Brainstem development Source: Ensembl
Cerebellum development Source: Ensembl
Cerebral cortex development Source: Ensembl
Glycine metabolic process Source: Ensembl
Purine nucleotide biosynthetic process Source: GO_Central
Purine ribonucleoside monophosphate biosynthetic process Source: Reactome
Response to inorganic substance Source: Ensembl
Response to organic substance Source: Ensembl
Tetrahydrofolate biosynthetic process Source: Ensembl

Cytosol; Extracellular exosome