GLP2R

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq]

glucagon-like peptide 2 receptor

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: InterPro
Positive regulation of cell population proliferation Source: ProtInc

Cell membrane

Extracellular: 1-173
Helical: 174-198
Cytoplasmic: 199-210
Helical: 211-235
Extracellular: 236-261
Helical: 262-285
Cytoplasmic: 286-299
Helical: 300-321
Extracellular: 322-339
Helical: 340-362
Cytoplasmic: 363-386
Helical: 387-405
Extracellular: 406-417
Helical: 418-438
Cytoplasmic: 439-550