HES6

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Full Name
Hes Family BHLH Transcription Factor 6
Function
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Negative regulation of DNA-binding transcription factor activity Source: ARUK-UCL
Regulation of neurogenesis Source: GO_Central
Regulation of transcription, DNA-templated Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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Anti-HES6 antibodies

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Rabbit Anti-HES6 Recombinant Antibody (EG1504) (CBMAB-EN1798-LY)

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Target: HES6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1504
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Datasheet SDS

Mouse Anti-HES6 Recombinant Antibody (CBFYH-0968) (CBMAB-H1907-FY)

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Target: HES6
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYH-0968
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-HES6 Recombinant Antibody (CBFYH-0967) (CBMAB-H1906-FY)

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Target: HES6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0967
Application*: WB
Datasheet SDS

Mouse Anti-HES6 Recombinant Antibody (CBFYH-0965) (CBMAB-H1904-FY)

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Target: HES6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0965
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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