HHEX

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Full Name
Hematopoietically Expressed Homeobox
Function
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity).

Transcriptional repressor (By similarity).

Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982).

Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).

May play a role in hematopoietic differentiation (PubMed:8096636).
Biological Process
Anterior/posterior pattern specification Source: UniProtKB
B cell differentiation Source: BHF-UCL
Cell differentiation Source: GO_Central
DNA conformation change Source: BHF-UCL
mRNA export from nucleus Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Poly(A)+ mRNA export from nucleus Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of Wnt signaling pathway Source: UniProtKB
Protein localization to nucleus Source: BHF-UCL
Regulation of leukocyte proliferation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Nucleus
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Anti-HHEX antibodies

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HHEX Matched Antibody Pair (539) (APMAB-539LY)

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Target: HHEX
Specificity: Human
Datasheet SDS

Mouse Anti-HHEX Recombinant Antibody (1A5) (CBMAB-A3883-LY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 1A5
Application*: WB, E
Datasheet SDS

Mouse Anti-HHEX Recombinant Antibody (4E9) (CBMAB-A3881-LY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 4E9
Application*: WB, E
Datasheet SDS

Mouse Anti-HHEX Recombinant Antibody (4E2) (CBMAB-A3880-LY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4E2
Application*: WB, E
Datasheet SDS

Mouse Anti-HHEX Recombinant Antibody (CBFYH-1062) (CBMAB-H2006-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1062
Application*: WB
Datasheet SDS

Mouse Anti-HHEX Recombinant Antibody (CBFYH-1061) (CBMAB-H2005-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1061
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-HHEX (AA 133-237) Recombinant Antibody (CBFYH-1059) (CBMAB-H2003-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1059
Application*: E, WB
Datasheet SDS

Mouse Anti-HHEX (AA 1-271) Recombinant Antibody (CBFYH-1057) (CBMAB-H2001-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBFYH-1057
Application*: E, WB
Datasheet SDS

Mouse Anti-HHEX (AA 100-270) Recombinant Antibody (CBFYH-1056) (CBMAB-H2000-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1056
Application*: WB, IF
Datasheet SDS

Mouse Anti-HHEX (AA 133-237) Recombinant Antibody (CBFYH-1055) (CBMAB-H1999-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1055
Application*: E, WB
Datasheet SDS

Mouse Anti-HHEX (AA 1-270) Recombinant Antibody (CBFYH-1054) (CBMAB-H1998-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1054
Application*: E, WB
Datasheet SDS

Mouse Anti-HHEX (AA 100-270) Recombinant Antibody (CBFYH-1052) (CBMAB-H1997-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1052
Application*: WB
Datasheet SDS

Mouse Anti-HHEX (AA 100-270) Recombinant Antibody (CBFYH-1051) (CBMAB-H1996-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1051
Application*: WB, IF
Datasheet SDS

Mouse Anti-HHEX (AA 100-270) Recombinant Antibody (CBFYH-1049) (CBMAB-H1994-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1049
Application*: IF, WB
Datasheet SDS

Mouse Anti-HHEX Monoclonal Antibody (CBFYH-3062) (CBMAB-H1993-FY)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3062
Application*: IP, WB
Datasheet SDS

Rabbit Anti-HHEX (AA 111-270) Recombinant Antibody (CBFYH-1053) (CBMAB-H0406-FY)

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Target: HHEX
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYH-1053
Application*: WB, F, IC
Datasheet SDS

Mouse Anti-HHEX Antibody (1D3) (CBMAB-0467-YC)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D3
Application*: IP, M
Datasheet SDS

Mouse Anti-HHEX Antibody (1C3) (CBMAB-0466-YC)

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Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C3
Application*: IP, WB, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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