HHEX
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Full Name
Hematopoietically Expressed Homeobox
Function
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity).
Transcriptional repressor (By similarity).
Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982).
Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).
May play a role in hematopoietic differentiation (PubMed:8096636).
Transcriptional repressor (By similarity).
Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982).
Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).
May play a role in hematopoietic differentiation (PubMed:8096636).
Biological Process
Anterior/posterior pattern specification Source: UniProtKB
B cell differentiation Source: BHF-UCL
Cell differentiation Source: GO_Central
DNA conformation change Source: BHF-UCL
mRNA export from nucleus Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Poly(A)+ mRNA export from nucleus Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of Wnt signaling pathway Source: UniProtKB
Protein localization to nucleus Source: BHF-UCL
Regulation of leukocyte proliferation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
B cell differentiation Source: BHF-UCL
Cell differentiation Source: GO_Central
DNA conformation change Source: BHF-UCL
mRNA export from nucleus Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Poly(A)+ mRNA export from nucleus Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of Wnt signaling pathway Source: UniProtKB
Protein localization to nucleus Source: BHF-UCL
Regulation of leukocyte proliferation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Nucleus
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Anti-HHEX antibodies
+ Filters
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CompareTarget: HHEX
Specificity: Human
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 1A5
Application*: WB, E
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 4E9
Application*: WB, E
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4E2
Application*: WB, E
Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1062
Application*: WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1061
Application*: E, IF, WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1059
Application*: E, WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBFYH-1057
Application*: E, WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1056
Application*: WB, IF
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1055
Application*: E, WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1054
Application*: E, WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1052
Application*: WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1051
Application*: WB, IF
Target: HHEX
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1049
Application*: IF, WB
Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3062
Application*: IP, WB
Target: HHEX
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYH-1053
Application*: WB, F, IC
Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D3
Application*: IP, M
Target: HHEX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C3
Application*: IP, WB, M
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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