HIV-2 Gag

Gag polyprotein: Mediates, with Gag-Pol polyrotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi).

Full Name

Human Immunodeficiency Virus Type 1 Capsid Protein P24

Function

Mediates, with Gag-Pol polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi).

Biological Process

Viral budding via host ESCRT complex Source: UniProtKB-KW

Cellular Location

Host cell membrane; Host multivesicular body. These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly.

PTM

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.