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ID3

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
Full Name
ID3
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Biological Process
Cell differentiation Source: GO_Central
Cellular response to leptomycin B Source: Ensembl
Central nervous system development Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Epithelial cell differentiation Source: Ensembl
Heart development Source: Ensembl
Metanephros development Source: Ensembl
Multicellular organism development Source: ProtInc
Muscle organ development Source: UniProtKB-KW
Negative regulation of DNA-binding transcription factor activity Source: GDB
Negative regulation of gene expression Source: Ensembl
Negative regulation of myoblast differentiation Source: Ensembl
Negative regulation of osteoblast differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Neuron differentiation Source: Ensembl
Notochord development Source: Ensembl
Odontogenesis Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Regulation of cell cycle Source: Ensembl
Regulation of DNA replication Source: Ensembl
Response to wounding Source: Ensembl
Cellular Location
Nucleus

Anti-ID3 antibodies

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Target: ID3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C8
Application*: IP, M
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G4
Application*: IP, M
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D6
Application*: IP, WB, M
Target: ID3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E10
Application*: WB, E
Target: ID3
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 2H8
Application*: WB, E
Target: ID3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Dog
Clone: D16D10
Application*: WB, IP, IF (IC), F
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 2B11
Application*: WB, IP, F, IC
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0586
Application*: WB, IH, IF, E
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0587
Application*: IH, WB, E
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D1
Application*: F, IF, WB
Target: ID3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G1
Application*: E, WB
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B6
Application*: IF, IH, P, WB
Target: ID3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I1568
Application*: WB
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1874
Application*: WB, IH, F
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2126
Application*: WB, IH, IF
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1879
Application*: WB, IH, IF, F
Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 8B3
Application*: WB, F, IH, IF, P
Target: ID3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5C7
Application*: F, IF, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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