ID3

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
Full Name
ID3
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Biological Process
Cell differentiation Source: GO_Central
Cellular response to leptomycin B Source: Ensembl
Central nervous system development Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Epithelial cell differentiation Source: Ensembl
Heart development Source: Ensembl
Metanephros development Source: Ensembl
Multicellular organism development Source: ProtInc
Muscle organ development Source: UniProtKB-KW
Negative regulation of DNA-binding transcription factor activity Source: GDB
Negative regulation of gene expression Source: Ensembl
Negative regulation of myoblast differentiation Source: Ensembl
Negative regulation of osteoblast differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Neuron differentiation Source: Ensembl
Notochord development Source: Ensembl
Odontogenesis Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Regulation of cell cycle Source: Ensembl
Regulation of DNA replication Source: Ensembl
Response to wounding Source: Ensembl
Cellular Location
Nucleus
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Anti-ID3 antibodies

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Rabbit Anti-ID3 Recombinant Antibody (D16D10) (CBMAB-CP1089-LY)

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Target: ID3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Dog
Clone: D16D10
Application*: WB, IP, IF (IC), F
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (2H8) (CBMAB-A4215-LY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 2H8
Application*: WB, E
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (3E10) (CBMAB-A4214-LY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E10
Application*: WB, E
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (CBYY-I2126) (CBMAB-I3296-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2126
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (CBYY-I1879) (CBMAB-I3049-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1879
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (CBYY-I1874) (CBMAB-I3044-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1874
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (CBYY-I1568) (CBMAB-I2738-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I1568
Application*: WB
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (8B3) (CBMAB-I1751-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 8B3
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (7B6) (CBMAB-I1652-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B6
Application*: IF, IH, P, WB
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (5C7) (CBMAB-I1429-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5C7
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (4G1) (CBMAB-I1345-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G1
Application*: E, WB
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (4D1) (CBMAB-I1320-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D1
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (CBYY-I0587) (CBMAB-I1290-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0587
Application*: IH, WB, E
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (CBYY-I0586) (CBMAB-I1289-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0586
Application*: WB, IH, IF, E
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (2B11) (CBMAB-I0236-YY)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 2B11
Application*: WB, IP, F, IC
Datasheet SDS

Mouse Anti-ID3 Recombinant Antibody (CBT2212) (V2LY-0625-LY1976)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT2212
Application*: IH, F
Datasheet SDS

Mouse Anti-ID3 Antibody (3D6) (CBMAB-0520-YC)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D6
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-ID3 Antibody (2G4) (CBMAB-0518-YC)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G4
Application*: IP, M
Datasheet SDS

Mouse Anti-ID3 Antibody (2C8) (CBMAB-0517-YC)

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Target: ID3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C8
Application*: IP, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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