IGLC1

IGLC1 (Immunoglobulin Lambda Constant 1) is a Protein Coding gene. Among its related pathways are Creation of C4 and C2 activators and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.
Full Name
Immunoglobulin lambda constant 1
Function
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Biological Process
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Cellular Location
Secreted; Cell membrane
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Anti-IGLC1 antibodies

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Mouse Anti-IGLC1 Recombinant Antibody (ICO106) (CBMAB-L0093-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ICO106
Application*: WB, F, E, IC, IF, IP, P, C, MC
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (5E702) (CBMAB-L0087-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5E702
Application*: E, IH
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (5F67) (CBMAB-L0113-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F67
Application*: F, IF
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-061) (CBMAB-L0112-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-061
Application*: IH
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-060) (CBMAB-L0111-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-060
Application*: E, WB, P
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-059) (CBMAB-L0110-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-059
Application*: E, WB
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-057) (CBMAB-L0108-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-057
Application*: E, P, C, F
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (SPM559) (CBMAB-L0107-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM559
Application*: WB, F, E, IC, IF, P, C
Datasheet SDS

Rabbit Anti-IGLC1 Recombinant Antibody (CBYJL-056) (CBMAB-L0106-YJ)

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Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-056
Application*: P, WB
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (Rs4) (CBMAB-L0105-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Rs4
Application*: E, IC, IF
Datasheet SDS

Rabbit Anti-IGLC1 Recombinant Antibody (RM127) (CBMAB-L0104-YJ)

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Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM127
Application*: IC, IH, F, E
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (Mc24-IC6) (CBMAB-L0102-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Mc24-IC6
Application*: F, E
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (LLC/1738) (CBMAB-L0101-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LLC/1738
Application*: WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (LcN-2) (CBMAB-L0099-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: LcN-2
Application*: WB, F, E, IH, IC, IF, P, C
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (LAM03) (CBMAB-L0097-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LAM03
Application*: WB, F, E, IC, IF, P, C
Datasheet SDS

Rabbit Anti-IGLC1 Recombinant Antibody (K22-Y) (CBMAB-L0096-YJ)

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Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: K22-Y
Application*: P, C
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (JDC-12) (CBMAB-L0095-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: JDC-12
Application*: WB, E, C, DB, IC, IF
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (HP6054) (CBMAB-L0092-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: HP6054
Application*: WB, F, E, IC, IF, IP, P, C
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-054) (CBMAB-L0091-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-054
Application*: F
Datasheet SDS

Rabbit Anti-IGLC1 Recombinant Antibody (CBYJL-053) (CBMAB-L0090-YJ)

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Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-053
Application*: WB, E
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-052) (CBMAB-L0089-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJL-052
Application*: F, IF
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-051) (CBMAB-L0088-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-051
Application*: E, IH
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (5E701) (CBMAB-L0086-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5E701
Application*: E, WB
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-050) (CBMAB-L0085-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-050
Application*: E, P, F
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (4C2) (CBMAB-L0084-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C2
Application*: F, E, P, C
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-049) (CBMAB-L0083-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-049
Application*: P, C
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (3D12) (CBMAB-L0081-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3D12
Application*: WB, IH, P, C
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-047) (CBMAB-L0080-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-047
Application*: WB, E
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-046) (CBMAB-L0079-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-046
Application*: E, IH, P, C
Datasheet SDS

Mouse Anti-IGLC1 Recombinant Antibody (1-155-2) (CBMAB-L0078-YJ)

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Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1-155-2
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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