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IGLC1

IGLC1 (Immunoglobulin Lambda Constant 1) is a Protein Coding gene. Among its related pathways are Creation of C4 and C2 activators and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.
Full Name
Immunoglobulin lambda constant 1
Function
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Biological Process
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Cellular Location
Secreted; Cell membrane

Anti-IGLC1 antibodies

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Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-054) (CBMAB-L0091-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-054
Application*: F

Mouse Anti-IGLC1 Recombinant Antibody (HP6054) (CBMAB-L0092-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: HP6054
Application*: WB, F, E, IC, IF, IP, P, C

Mouse Anti-IGLC1 Recombinant Antibody (JDC-12) (CBMAB-L0095-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: JDC-12
Application*: WB, E, C, DB, IC, IF

Rabbit Anti-IGLC1 Recombinant Antibody (K22-Y) (CBMAB-L0096-YJ)

Datasheet SDS
Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: K22-Y
Application*: P, C

Mouse Anti-IGLC1 Recombinant Antibody (5F67) (CBMAB-L0113-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F67
Application*: F, IF

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-061) (CBMAB-L0112-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-061
Application*: IH

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-060) (CBMAB-L0111-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-060
Application*: E, WB, P

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-059) (CBMAB-L0110-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-059
Application*: E, WB

Mouse Anti-IGLC1 Recombinant Antibody (1-155-2) (CBMAB-L0078-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1-155-2
Application*: F

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-046) (CBMAB-L0079-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-046
Application*: E, IH, P, C

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-047) (CBMAB-L0080-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-047
Application*: WB, E

Mouse Anti-IGLC1 Recombinant Antibody (3D12) (CBMAB-L0081-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3D12
Application*: WB, IH, P, C

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-049) (CBMAB-L0083-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-049
Application*: P, C

Mouse Anti-IGLC1 Recombinant Antibody (4C2) (CBMAB-L0084-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C2
Application*: F, E, P, C

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-050) (CBMAB-L0085-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-050
Application*: E, P, F

Mouse Anti-IGLC1 Recombinant Antibody (5E701) (CBMAB-L0086-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5E701
Application*: E, WB

Mouse Anti-IGLC1 Recombinant Antibody (5E702) (CBMAB-L0087-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5E702
Application*: E, IH

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-051) (CBMAB-L0088-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-051
Application*: E, IH

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-052) (CBMAB-L0089-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJL-052
Application*: F, IF

Rabbit Anti-IGLC1 Recombinant Antibody (CBYJL-053) (CBMAB-L0090-YJ)

Datasheet SDS
Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-053
Application*: WB, E

Mouse Anti-IGLC1 Recombinant Antibody (ICO106) (CBMAB-L0093-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ICO106
Application*: WB, F, E, IC, IF, IP, P, C, MC

Mouse Anti-IGLC1 Recombinant Antibody (LAM03) (CBMAB-L0097-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LAM03
Application*: WB, F, E, IC, IF, P, C

Mouse Anti-IGLC1 Recombinant Antibody (LcN-2) (CBMAB-L0099-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: LcN-2
Application*: WB, F, E, IH, IC, IF, P, C

Mouse Anti-IGLC1 Recombinant Antibody (LLC/1738) (CBMAB-L0101-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LLC/1738
Application*: WB, P, IF, IC, F

Mouse Anti-IGLC1 Recombinant Antibody (Mc24-IC6) (CBMAB-L0102-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Mc24-IC6
Application*: F, E

Rabbit Anti-IGLC1 Recombinant Antibody (RM127) (CBMAB-L0104-YJ)

Datasheet SDS
Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM127
Application*: IC, IH, F, E

Mouse Anti-IGLC1 Recombinant Antibody (Rs4) (CBMAB-L0105-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Rs4
Application*: E, IC, IF

Rabbit Anti-IGLC1 Recombinant Antibody (CBYJL-056) (CBMAB-L0106-YJ)

Datasheet SDS
Target: IGLC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-056
Application*: P, WB

Mouse Anti-IGLC1 Recombinant Antibody (CBYJL-057) (CBMAB-L0108-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-057
Application*: E, P, C, F

Mouse Anti-IGLC1 Recombinant Antibody (SPM559) (CBMAB-L0107-YJ)

Datasheet SDS
Target: IGLC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM559
Application*: WB, F, E, IC, IF, P, C
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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