ITGB7

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Full Name
integrin beta 7
Alternative Names
Integrin Subunit Beta 7
Function
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-matrix adhesion involved in ameboidal cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
T cell migrationIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 20-723
Helical: 724-746
Cytoplasmic: 747-798
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Anti-ITGB7 antibodies

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Rat Anti-ITGB7 Recombinant Antibody (DATK32) (CBMAB-1050-LY)

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Target: ITGB7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: DATK32
Application*: N, F
Functional Assay
Datasheet SDS

Rat Anti-ITGB7 Recombinant Antibody (AG126) (V2LY-0524-LY56)

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Target: ITGB7
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AG126
Application*: B, MC, F, IP
Functional Assay
Datasheet SDS

Rat Anti-ITGB7 Recombinant Antibody (AG125) (V2LY-0524-LY55)

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Target: ITGB7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: AG125
Application*: B, F, In Vivo
In Vivo Assay Functional Assay
Datasheet SDS

Mouse Anti-ITGB7 Recombinant Antibody (CBYY-I1414) (CBMAB-I2584-YY)

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Target: ITGB7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1414
Application*: E, F, IC
Datasheet SDS

Mouse Anti-ITGB7 Recombinant Antibody (8D3) (CBMAB-I1754-YY)

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Target: ITGB7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8D3
Application*: E, IF
Datasheet SDS

Human Anti-ITGB7 Recombinant Antibody (CBYY-I0416) (CBMAB-I1014-YY)

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Target: ITGB7
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I0416
Application*: F
Datasheet SDS

Rat Anti-ITGB7 Recombinant Antibody (FIB504) (CBMAB-I0109-YY)

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Target: ITGB7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: FIB504
Application*: IP, WB, F
Datasheet SDS

Rat Anti-ITGB7 Recombinant Antibody (CBYY-I0044) (CBMAB-I0108-YY)

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Target: ITGB7
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human
Clone: CBYY-I0044
Application*: F, IP, BL
Datasheet SDS

Rat Anti-ITGB7 Recombinant Antibody (CBYY-I0043) (CBMAB-I0107-YY)

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Target: ITGB7
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I0043
Application*: F, IH, IP, P
Datasheet SDS

Mouse Anti-ITGB7 Recombinant Antibody (CBT3092) (V2LY-0625-LY1895)

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Target: ITGB7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3092
Application*: IH, F
Datasheet SDS

Mouse Anti-ITGB7 Recombinant Antibody (CBT4031) (V2LY-0625-LY1838)

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Target: ITGB7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4031
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-ITGB7 Recombinant Antibody (CBT4788) (V2LY-0625-LY1768)

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Target: ITGB7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4788
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-ITGB7 Recombinant Antibody (CBT2847) (V2LY-0625-LY1767)

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Target: ITGB7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2847
Application*: IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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