KAT2A

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner.

lysine acetyltransferase 2A

Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711).
Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711).
Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711).
Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711).
In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711).
Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755).
Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711).
Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837).
Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity).
Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity).
Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity).
Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity).
Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768).
Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768).
Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297).
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.

Alpha-tubulin acetylationIEA:Ensembl
Cell population proliferationIEA:Ensembl
Cellular response to nerve growth factor stimulusIEA:Ensembl
Cellular response to tumor necrosis factorIEA:Ensembl
Chromatin remodelingManual Assertion Based On ExperimentTAS:ProtInc
Heart developmentISS:UniProtKB
Histone acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K14 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone succinylationManual Assertion Based On ExperimentIDA:UniProtKB
In utero embryonic developmentIEA:Ensembl
Internal peptidyl-lysine acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular distribution of mitochondriaIEA:Ensembl
Limb developmentISS:UniProtKB
Long-term memoryISS:UniProtKB
Metencephalon developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Monoubiquitinated histone deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Monoubiquitinated histone H2A deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Multicellular organism growthIEA:Ensembl
Negative regulation of centriole replicationManual Assertion Based On ExperimentIDA:UniProtKB
Neural tube closureIEA:Ensembl
Peptidyl-lysine glutarylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cardiac muscle cell differentiationIEA:Ensembl
Positive regulation of cell projection organizationIEA:Ensembl
Positive regulation of cytokine productionISS:UniProtKB
Positive regulation of gluconeogenesisIEA:Ensembl
Positive regulation of histone acetylationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of bone developmentISS:UniProtKB
Regulation of cartilage developmentISS:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of cell divisionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of embryonic developmentIEA:Ensembl
Regulation of histone deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of protein stabilityManual Assertion Based On ExperimentIMP:MGI
Regulation of regulatory T cell differentiationISS:UniProtKB
Regulation of stem cell population maintenanceISS:UniProtKB
Regulation of synaptic plasticityISS:UniProtKB
Regulation of T cell activationISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of tubulin deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Response to nutrient levelsIEA:Ensembl
Response to organic cyclic compoundIEA:Ensembl
SomitogenesisIEA:Ensembl
Telencephalon developmentIEA:Ensembl

Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to the nucleus (PubMed:27796307).
Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307).