KCNK5

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq]

Full Name

potassium channel, subfamily K, member 5

Function

pH-dependent, outwardly rectifying potassium channel (PubMed:9812978).
Outward rectification is lost at high external K(+) concentrations (PubMed:9812978).

Biological Process

ExcretionManual Assertion Based On ExperimentTAS:ProtInc
Potassium ion export across plasma membraneISS:ARUK-UCL
Potassium ion import across plasma membraneIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Regulation of resting membrane potentialISS:ARUK-UCL
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-7
Helical: 8-26
Pore-forming: 85-112
Helical: 113-133
Cytoplasmic: 134-157
Helical: 158-180
Pore-forming: 190-215
Helical: 230-250
Cytoplasmic: 251-325