Mouse Anti-KCNK5 Recombinant Antibody (2B4) (CBMAB-K0588-LY)

Name: Mouse Anti-KCNK5 Recombinant Antibody (2B4)
SKU: CBMAB-K0588-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B4

Application

ELISA

Immunogen

KCNK5 (1 a.a. ~ 499 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium channel, subfamily K, member 5

Introduction

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

Entrez Gene ID

8645

UniProt ID

O95279

Alternative Names

Potassium Two Pore Domain Channel Subfamily K Member 5; Potassium Channel; Two Pore Domain Subfamily K; Member 5; Acid-Sensitive Potassium Channel Protein TASK-2; TWIK-Related Acid-Sensitive K(+) Channel 2; TASK2; Potassium Channel; Subfamily K; Member 1 (TASK-2); Potassium Channel; Subfamily; Member 5 (KCNK5); Potassium Channel; Subfamily K; Member 5;

Function

pH-dependent, outwardly rectifying potassium channel (PubMed:9812978).
Outward rectification is lost at high external K(+) concentrations (PubMed:9812978).

Biological Process

ExcretionManual Assertion Based On ExperimentTAS:ProtInc
Potassium ion export across plasma membraneISS:ARUK-UCL
Potassium ion import across plasma membraneIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Regulation of resting membrane potentialISS:ARUK-UCL
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-7
Helical: 8-26
Pore-forming: 85-112
Helical: 113-133
Cytoplasmic: 134-157
Helical: 158-180
Pore-forming: 190-215
Helical: 230-250
Cytoplasmic: 251-325

Jiang, Z., Zhao, L., Zhang, X., Zhang, W., Feng, Y., & Li, T. (2021). Common variants in KCNK5 and FHL5 genes contributed to the susceptibility of migraine without aura in Han Chinese population. Scientific Reports, 11(1), 6807.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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