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Mouse Anti-KCNK5 Recombinant Antibody (2B4) (CBMAB-K0588-LY)

This product is antibody recognizes KCNK5. The antibody 2B4 immunoassay techniques such as: ELISA.
See all KCNK5 antibodies
Published Data
Fig. 1 Immunofluorescence confirms the presence of KCNK channels at the apical membrane.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B4
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
KCNK5 (1 a.a. ~ 499 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium channel, subfamily K, member 5
Introduction
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Entrez Gene ID
8645
UniProt ID
O95279
Alternative Names
Potassium Two Pore Domain Channel Subfamily K Member 5; Potassium Channel; Two Pore Domain Subfamily K; Member 5; Acid-Sensitive Potassium Channel Protein TASK-2; TWIK-Related Acid-Sensitive K(+) Channel 2; TASK2; Potassium Channel; Subfamily K; Member 1 (TASK-2); Potassium Channel; Subfamily; Member 5 (KCNK5); Potassium Channel; Subfamily K; Member 5;
Function
pH-dependent, outwardly rectifying potassium channel (PubMed:9812978).
Outward rectification is lost at high external K(+) concentrations (PubMed:9812978).
Biological Process
ExcretionManual Assertion Based On ExperimentTAS:ProtInc
Potassium ion export across plasma membraneISS:ARUK-UCL
Potassium ion import across plasma membraneIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Regulation of resting membrane potentialISS:ARUK-UCL
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Cytoplasmic: 1-7
Helical: 8-26
Pore-forming: 85-112
Helical: 113-133
Cytoplasmic: 134-157
Helical: 158-180
Pore-forming: 190-215
Helical: 230-250
Cytoplasmic: 251-325
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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