KIF3A

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.

Full Name

Kinesin Family Member 3A

Function

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.

Biological Process

Anterograde axonal transportManual Assertion Based On ExperimentIBA:GO_Central
Centriole-centriole cohesionISS:UniProtKB
Cilium assemblyISS:UniProtKB
Microtubule anchoring at centrosomeISS:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Organelle organizationManual Assertion Based On ExperimentTAS:ProtInc
Plus-end-directed vesicle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Protein localization to cell junctionManual Assertion Based On ExperimentIMP:BHF-UCL
Protein transportManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cytoplasm, cytoskeleton; Cell projection, cilium; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localizes to the subdistal appendage region of the centriole.