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LDB2

LIM-domain binding family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. LDB2 (LIM domain binding 2) belongs to the LIM-domain binding family. LDB2 may function in rhegmatogenous retinal detachment and coronary artery disease.

Full Name

LDB2

Function

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

Biological Process

Epithelial structure maintenanceIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular component biogenesisIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationISS:UniProtKB
Regulation of kinase activityISS:UniProtKB
Somatic stem cell population maintenanceIEA:Ensembl

Cellular Location

Nucleus

PTM

Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.

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Anti-LDB2 antibodies

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Mouse Anti-LDB2 Recombinant Antibody (1C3) (CBMAB-A4893-LY)

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Target: LDB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C3

Application*: WB, E

Mouse Anti-LDB2 Recombinant Antibody (CBYCL-181) (CBMAB-L0082-YC)

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Target: LDB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-181

Application*: E, IC, WB

Mouse Anti-LDB2 Recombinant Antibody (CBYCL-180) (CBMAB-L0081-YC)

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Target: LDB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYCL-180

Application*: E, WB

Mouse Anti-LDB2 Recombinant Antibody (CBYJL-1330) (CBMAB-L0918-YJ)

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Target: LDB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJL-1330

Application*: E, IF, WB

Mouse Anti-LDB2 Recombinant Antibody (1A3) (CBMAB-L0916-YJ)

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Target: LDB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A3

Application*: IF, WB

Mouse Anti-LDB2 Antibody (1A10) (CBMAB-0612-YC)

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Target: LDB2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1A10

Application*: E, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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