LIN7B

Diseases associated with LIN7B include Retinitis Pigmentosa 24. Among its related pathways are Transmission across Chemical Synapses and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and L27 domain binding. An important paralog of this gene is LIN7C. LIN7B plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. LIN7B forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. It ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. LIN7B may increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Full Name

Lin-7 Homolog B, Crumbs Cell Polarity Complex Component

Function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Biological Process

ExocytosisIEA:UniProtKB-KW
Maintenance of epithelial cell apical/basal polarityManual Assertion Based On ExperimentIBA:GO_Central
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to basolateral plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW

Cellular Location

Cell membrane
Basolateral cell membrane
Cell junction
Cell junction, synapse, postsynaptic density membrane
Cell junction, tight junction
Mainly basolateral in renal epithelial cells.