LIN7C

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene. This protein plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains.

Full Name

LIN7C

Function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Biological Process

ExocytosisIEA:UniProtKB-KW
Maintenance of epithelial cell apical/basal polarityManual Assertion Based On ExperimentIBA:GO_Central
Morphogenesis of an epithelial sheetManual Assertion Based On ExperimentIMP:UniProtKB
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to basolateral plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW

Cellular Location

Cell membrane
Basolateral cell membrane
Cell junction
Cell junction, synapse, postsynaptic density membrane
Cell junction, tight junction
Mainly basolateral in renal epithelial cells.