myod1

This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]

Myogenic Differentiation 1

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).

Cellular response to estradiol stimulus Source: UniProtKB
Cellular response to glucocorticoid stimulus Source: Ensembl
Cellular response to oxygen levels Source: Ensembl
Cellular response to starvation Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Histone H3 acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Muscle cell fate commitment Source: BHF-UCL
Muscle organ development Source: ProtInc
Myoblast fate determination Source: Ensembl
Myoblast fusion Source: Ensembl
Myotube cell development Source: BHF-UCL
Myotube differentiation involved in skeletal muscle regeneration Source: Ensembl
Negative regulation of chromatin binding Source: Ensembl
Negative regulation of myoblast proliferation Source: Ensembl
Positive regulation of binding Source: Ensembl
Positive regulation of muscle cell differentiation Source: BHF-UCL
Positive regulation of myoblast differentiation Source: GO_Central
Positive regulation of myoblast fusion Source: BHF-UCL
Positive regulation of skeletal muscle fiber development Source: GO_Central
Positive regulation of skeletal muscle tissue regeneration Source: Ensembl
Positive regulation of snRNA transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Protein phosphorylation Source: ProtInc
Regulation of alternative mRNA splicing, via spliceosome Source: Ensembl
Regulation of RNA splicing Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: GO_Central
Skeletal muscle fiber adaptation Source: Ensembl
Skeletal muscle fiber development Source: Ensembl
Skeletal muscle tissue development Source: ProtInc

Nucleus

Myopathy, congenital, with diaphragmatic defects, respiratory insufficiency, and dysmorphic facies (MYODRIF):
An autosomal recessive muscular disorder characterized by hypotonia and respiratory insufficiency apparent soon after birth, high diaphragmatic dome on imaging, poor overall growth, pectus excavatum, dysmorphic facies, and renal anomalies in some affected individuals. Additional variable features include delayed motor development, mildly decreased endurance, distal arthrogryposis, and lung hypoplasia resulting in early death.

Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
Ubiquitinated on the N-terminus; which is required for proteasomal degradation.
Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.