NEK6

The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM

NIMA (never in mitosis gene a)-related kinase 6

Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848).

Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596).

Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783).

Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501).

Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393).

Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361).

Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).

Apoptotic process Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Chromosome segregation Source: UniProtKB
Mitotic nuclear membrane disassembly Source: Reactome
Mitotic spindle organization Source: Reactome
Peptidyl-serine phosphorylation Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cellular senescence Source: UniProtKB
Regulation of mitotic cell cycle Source: UniProtKB
Regulation of mitotic metaphase/anaphase transition Source: UniProtKB
Spindle assembly Source: UniProtKB

Nucleus
Nucleus speckle
Cytoplasm
Cytoskeleton
centrosome
spindle pole
Note: Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.

Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210.