NFATC2
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [
Full Name
NFATC2
Function
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.
Biological Process
B cell receptor signaling pathway Source: UniProtKB
Calcineurin-NFAT signaling cascade Source: GO_Central
Cell migration Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Myotube cell development Source: Ensembl
Negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of gene expression Source: Ensembl
Positive regulation of myoblast fusion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: MGI
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to xenobiotic stimulus Source: UniProtKB
Calcineurin-NFAT signaling cascade Source: GO_Central
Cell migration Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Myotube cell development Source: Ensembl
Negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of gene expression Source: Ensembl
Positive regulation of myoblast fusion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: MGI
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to xenobiotic stimulus Source: UniProtKB
Cellular Location
Nucleus
Cytoplasm
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Cytoplasm
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
PTM
In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity.
Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.
Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.
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Anti-NFATC2 antibodies
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CompareTarget: NFATC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 16A12A31
Application*: WB
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: G1-G9
Application*: IF, WB
Target: NFATC2
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBWJN-0605
Application*: IP, IF
Target: NFATC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1362
Application*: WB
Target: NFATC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D9C2
Application*: WB, IP
Target: NFATC2
Host: Mouse
Specificity: Human
Clone: A-2
Application*: WB, IP, IF, E
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJN-0463
Application*: IC, IP, WB
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse, Rat
Clone: CBWJN-0462
Application*: WB, IP, IC
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBWJN-0419
Application*: WB, IP, IF, P
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1361
Application*: WB
Target: NFATC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D43B1
Application*: WB, IP, P, IF, F
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A4
Application*: E, WB
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 25A10.D6.D2
Application*: WB, CI, IF, IP, P, C, SE
Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBWJN-0984
Application*: WB, IF, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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