NFATC2

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [
Full Name
NFATC2
Function
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.
Biological Process
B cell receptor signaling pathway Source: UniProtKB
Calcineurin-NFAT signaling cascade Source: GO_Central
Cell migration Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Myotube cell development Source: Ensembl
Negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of gene expression Source: Ensembl
Positive regulation of myoblast fusion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: MGI
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to xenobiotic stimulus Source: UniProtKB
Cellular Location
Nucleus
Cytoplasm
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
PTM
In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity.
Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.
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Anti-NFATC2 antibodies

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Mouse Anti-NFATC2 Recombinant Antibody (16A12A31) (CBMAB-N2157-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 16A12A31
Application*: WB
Datasheet SDS

Mouse Anti-NFATC2 Antibody (G1-G9) (CBMAB-1454CQ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: G1-G9
Application*: IF, WB
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (CBWJN-0605) (CBMAB-N2164-WJ)

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Target: NFATC2
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBWJN-0605
Application*: IP, IF
Datasheet SDS

Rabbit Anti-NFATC2 Recombinant Antibody (CBWJN-1362) (CBMAB-N2163-WJ)

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Target: NFATC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1362
Application*: WB
Datasheet SDS

Rabbit Anti-NFATC2 Recombinant Antibody (D9C2) (CBMAB-N2162-WJ)

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Target: NFATC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D9C2
Application*: WB, IP
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (A-2) (CBMAB-N2161-WJ)

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Target: NFATC2
Host: Mouse
Specificity: Human
Clone: A-2
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (CBWJN-0463) (CBMAB-N2160-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJN-0463
Application*: IC, IP, WB
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (CBWJN-0462) (CBMAB-N2159-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse, Rat
Clone: CBWJN-0462
Application*: WB, IP, IC
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (CBWJN-0419) (CBMAB-N2158-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBWJN-0419
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (CBWJN-1361) (CBMAB-N2155-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1361
Application*: WB
Datasheet SDS

Rabbit Anti-NFATC2 Recombinant Antibody (D43B1) (CBMAB-N0299-WJ)

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Target: NFATC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D43B1
Application*: WB, IP, P, IF, F
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (2A4) (CBMAB-N0298-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A4
Application*: E, WB
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (25A10.D6.D2) (CBMAB-N0297-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 25A10.D6.D2
Application*: WB, CI, IF, IP, P, C, SE
Datasheet SDS

Mouse Anti-NFATC2 Recombinant Antibody (CBWJN-0984) (CBMAB-N0296-WJ)

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Target: NFATC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBWJN-0984
Application*: WB, IF, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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