NFIB

Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Full Name

NFIB

Function

Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402).
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Biological Process

Anterior commissure morphogenesisISS:UniProtKB
Brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cell differentiation involved in salivary gland developmentIEA:Ensembl
Chondrocyte differentiationISS:UniProtKB
Club cell differentiationISS:UniProtKB
Commissural neuron axon guidanceISS:UniProtKB
DNA replicationIEA:UniProtKB-KW
Glial cell differentiationISS:UniProtKB
Hindbrain developmentIEA:Ensembl
Lung ciliated cell differentiationISS:UniProtKB
Negative regulation of DNA bindingIDA:UniProtKB
Negative regulation of epithelial cell proliferation involved in lung morphogenesisISS:UniProtKB
Negative regulation of mesenchymal cell proliferation involved in lung developmentISS:UniProtKB
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription by RNA polymerase IIIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Principal sensory nucleus of trigeminal nerve developmentISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to bacteriumIEA:Ensembl
Salivary gland cavitationIEA:Ensembl
Type I pneumocyte differentiationISS:UniProtKB
Type II pneumocyte differentiationISS:UniProtKB

Cellular Location

Nucleus

Involvement in disease

Macrocephaly, acquired, with impaired intellectual development (MACID):
An autosomal dominant disorder characterized by postnatal macrocephaly and borderline to mild mental retardation. Additional variable neurodevelopmental features include muscular hypotonia, motor and speech delay, attention deficit disorder, autism spectrum disorder, and behavioral abnormalities. Some patients present corpus callosum dysgenesis.