NIT1

This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
nitrilase 1
Function
Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.
Biological Process
Cellular amide catabolic processBy SimilarityISS:ARUK-UCL
Cellular Location
Isoform 2
Mitochondrion
Isoform 1
Cytoplasm
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Anti-NIT1 antibodies

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Mouse Anti-NIT1 Recombinant Antibody (D-7) (CBMAB-N2488-WJ)

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Target: NIT1
Host: Mouse
Specificity: Human
Clone: D-7
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NIT1 Recombinant Antibody (3A11) (CBMAB-N2486-WJ)

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Target: NIT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A11
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-NIT1 Recombinant Antibody (1C3) (CBMAB-N2485-WJ)

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Target: NIT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C3
Application*: E, IF, IP, WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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