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NPM2

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.

Full Name

nucleophosmin/nucleoplasmin, 2

Function

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.

Biological Process

Blastocyst developmentManual Assertion Based On ExperimentIMP:UniProtKB
Chromatin remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Oocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of meiotic nuclear divisionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of exit from mitosisManual Assertion Based On ExperimentIMP:UniProtKB
Single fertilizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.

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Anti-NPM2 antibodies

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Mouse Anti-NPM2 Recombinant Antibody (CBT4550) (V2LY-0625-LY1953)

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Target: NPM2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBT4550

Application*: IH, IC

Mouse Anti-NPM2 Recombinant Antibody (CBT4769) (V2LY-0625-LY1952)

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Target: NPM2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4769

Application*: IH, F

Mouse Anti-NPM2 Recombinant Antibody (5E9) (CBMAB-N3162-WJ)

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Target: NPM2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5E9

Application*: E, IF, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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