OLFM1

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq]

olfactomedin 1

Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity).
May play an important role in regulating the production of neural crest cells by the neural tube (By similarity).
May be required for normal responses to olfactory stimuli (By similarity).

Atrioventricular valve formationISS:AgBase
Cardiac epithelial to mesenchymal transitionISS:AgBase
Negative regulation of gene expressionISS:AgBase
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuronal signal transductionISS:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial to mesenchymal transitionISS:AgBase
Positive regulation of gene expressionISS:AgBase
Regulation of axon extensionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Secreted
Cell junction, synapse
Endoplasmic reticulum
Cell projection, axon
Perikaryon