OLFM1
This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
olfactomedin 1
Function
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity).
May play an important role in regulating the production of neural crest cells by the neural tube (By similarity).
May be required for normal responses to olfactory stimuli (By similarity).
May play an important role in regulating the production of neural crest cells by the neural tube (By similarity).
May be required for normal responses to olfactory stimuli (By similarity).
Biological Process
Atrioventricular valve formationISS:AgBase
Cardiac epithelial to mesenchymal transitionISS:AgBase
Negative regulation of gene expressionISS:AgBase
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuronal signal transductionISS:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial to mesenchymal transitionISS:AgBase
Positive regulation of gene expressionISS:AgBase
Regulation of axon extensionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cardiac epithelial to mesenchymal transitionISS:AgBase
Negative regulation of gene expressionISS:AgBase
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuronal signal transductionISS:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial to mesenchymal transitionISS:AgBase
Positive regulation of gene expressionISS:AgBase
Regulation of axon extensionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cell junction, synapse
Endoplasmic reticulum
Cell projection, axon
Perikaryon
Cell junction, synapse
Endoplasmic reticulum
Cell projection, axon
Perikaryon
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Anti-OLFM1 antibodies
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Target: OLFM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E9-1A2
Application*: SE, E
Target: OLFM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXO-0291
Application*: E
Target: OLFM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0462
Application*: E
Target: OLFM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: S96-7
Application*: WB, IH, IF
Target: OLFM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G12-1B3
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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