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Mouse Anti-OLFM1 Recombinant Antibody (S96-7) (CBMAB-O0353-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S96-7
Antibody Isotype
IgG1
Application
WB, IHC, IF

Basic Information

Immunogen
Synthetic peptide of amino acids 28-48 of human pancortin-1 (SLVGLNTTRLSAASGGTLDRS)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS pH 7.4, 50% glycerol
Preservative
0.09% Sodium Azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
olfactomedin 1
Introduction
This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.
Entrez Gene ID
Human10439
Mouse56177
Rat93667
UniProt ID
HumanQ99784
MouseO88998
RatQ62609
Alternative Names
Olfactomedin 1; Neuronal Olfactomedin-Related ER Localized Protein; Noelin; NOE1; Olfactomedin Related ER Localized Protein; Neuroblastoma Protein; Olfactomedin-1
Function
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity).
May play an important role in regulating the production of neural crest cells by the neural tube (By similarity).
May be required for normal responses to olfactory stimuli (By similarity).
Biological Process
Atrioventricular valve formationISS:AgBase
Cardiac epithelial to mesenchymal transitionISS:AgBase
Negative regulation of gene expressionISS:AgBase
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuronal signal transductionISS:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial to mesenchymal transitionISS:AgBase
Positive regulation of gene expressionISS:AgBase
Regulation of axon extensionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cell junction, synapse
Endoplasmic reticulum
Cell projection, axon
Perikaryon
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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