ORC2

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
Full Name
Origin Recognition Complex Subunit 2
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
Biological Process
DNA replication initiationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
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Anti-ORC2 antibodies

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Mouse Anti-ORC2 Recombinant Antibody (CBXO-0402) (CBMAB-O0538-CQ)

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Target: ORC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0402
Application*: WB
Datasheet SDS

Rat Anti-ORC2 Recombinant Antibody (3G6) (CBMAB-O0536-CQ)

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Target: ORC2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3G6
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-ORC2 Recombinant Antibody (SB46) (CBMAB-O0535-CQ)

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Target: ORC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Yeast
Clone: SB46
Application*: IP, WB
Datasheet SDS

Mouse Anti-ORC2 Recombinant Antibody (CBXO-0284) (CBMAB-O0534-CQ)

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Target: ORC2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBXO-0284
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-ORC2 Recombinant Antibody (CBXO-0073) (CBMAB-O0533-CQ)

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Target: ORC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0073
Application*: WB
Datasheet SDS

Mouse Anti-ORC2 Recombinant Antibody (CBXO-0074) (CBMAB-O0532-CQ)

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Target: ORC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0074
Application*: WB, E, P, IF
Datasheet SDS

Mouse Anti-ORC2 Recombinant Antibody (3E11-1G5) (CBMAB-O0531-CQ)

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Target: ORC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E11-1G5
Application*: E, WB
Datasheet SDS

Rat Anti-ORC2 Recombinant Antibody (CBXO-0072) (CBMAB-O0530-CQ)

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Target: ORC2
Host: Rat
Specificity: Human
Clone: CBXO-0072
Application*: E, IC, IF, IP, WB
Datasheet SDS

Mouse Anti-ORC2 Antibody (ORC2) (CBMAB-0909-YC)

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Target: ORC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: C. elegans
Clone: ORC2
Application*: IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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