P2RY2

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene.

Full Name

purinergic receptor P2Y2

Research Area

Neuroscience,Signal transduction

Function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP> ATP-gamma-S>> 2-methylthio-ATP = ADP.

Biological Process

Blood vessel diameter maintenance
Cellular response to ATP
G protein-coupled receptor signaling pathway
Intracellular monoatomic ion homeostasis
Phospholipase C-activating G protein-coupled receptor signaling pathway
Positive regulation of mucus secretion

Cellular Location

Cell membrane ; Multi-pass membrane protein

Topology

Extracellular: 1-32
Helical: 33-59
Cytoplasmic: 60-70
Helical: 71-93
Extracellular: 94-110
Helical: 111-129
Cytoplasmic: 130-152
Helical: 153-172
Extracellular: 173-194
Helical: 195-220
Cytoplasmic: 221-246
Helical: 247-269
Extracellular: 270-287
Helical: 288-309
Cytoplasmic: 310-377