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PEBP1

This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

Full Name

Phosphatidylethanolamine Binding Protein 1

Function

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity).
Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Biological Process

Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

Anti-PEBP1 antibodies

Mouse Anti-PEBP1 Recombinant Antibody (4B11) (CBMAB-R0615-CN)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4B11

Application*: WB, E, IF

Mouse Anti-PEBP1 Recombinant Antibody (6A175) (CBMAB-R0616-CN)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6A175

Application*: IP, WB

Mouse Anti-PEBP1 Recombinant Antibody (CBCNR-537) (CBMAB-R0617-CN)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-537

Application*: E, WB

Rabbit Anti-PEBP1 Recombinant Antibody (D42F3) (CBMAB-R0618-CN)

SDS

Target: PEBP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D42F3

Application*: WB, P

Mouse Anti-PEBP1 Recombinant Antibody (1D3-1B6) (CBMAB-A6378-LY)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1D3-1B6

Application*: WB, E

Mouse Anti-PEBP1 Recombinant Antibody (2G2-1F1) (CBMAB-A6379-LY)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G2-1F1

Application*: WB, E

Rabbit Anti-PEBP1 Recombinant Antibody (EPR2875Y) (CBMAB-1663-CN)

SDS

Target: PEBP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EPR2875Y

Application*: IF, C, P, IP, WB

Rabbit Anti-PEBP1 Recombinant Antibody (EP2845Y) (CBMAB-1664-CN)

SDS

Target: PEBP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: EP2845Y

Application*: IC, P, WB

Mouse Anti-PEBP1 Antibody (10BA5) (CBMAB-1487CQ)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 10BA5

Application*: E, WB

Rabbit Anti-PEBP1 Recombinant Antibody (CBYC-P286) (CBMAB-P1406-YC)

SDS

Target: PEBP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Zebrafish

Clone: CBYC-P286

Application*: WB, P, IF, IC, IP

Mouse Anti-PEBP1 Recombinant Antibody (2G2-1F1) (CBMAB-P1404-YC)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2G2-1F1

Application*: E, WB

Mouse Anti-PEBP1 Recombinant Antibody (2D4D11) (CBMAB-P1403-YC)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 2D4D11

Application*: E, WB, IH

Mouse Anti-PEBP1 Recombinant Antibody (2D4) (CBMAB-P1402-YC)

SDS

Target: PEBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2D4

Application*: WB

PEBP1 Matched Antibody Pair (861) (APMAB-861LY)

SDS

Target: PEBP1

Specificity: Human

PEBP1 Matched Antibody Pair (862) (APMAB-862LY)

SDS

Target: PEBP1

Specificity: Human

PEBP1 Matched Antibody Pair (863) (APMAB-863LY)

SDS

Target: PEBP1

Specificity: Human

PEBP1 Matched Antibody Pair (864) (APMAB-864LY)

SDS

Target: PEBP1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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